Maxum (Cefepime) Injection is sterile, injectable product consisting of Cefepime
Hydrochloride, a semi-synthetic, broad spectrum, cephalosporin antibiotic for
DOSAGE AND ADMINISTRATION
Adults and Pediatric Population;
The recommended adult and pediatric dosages and routes of administration are
outlined below. Maxum (Cefepime) Injection should be administered intravenously
over approximately 30 minutes.
Recommended Dosage Schedule for Cefepime Injection in Patients with CrCL
Greater Than 60 mL/min
Site and Type of Infection Dose Frequency Duration (days) Adults
Moderate to Severe Pneumonia
1-2 g IV Every 12 hours 10 Empiric therapy for febrile neutropenic patients 2 g IV Every 8 hours 7 Mild to Moderate Uncomplicated or Complicated Urinary Tract Infections, including pyelonephritis 0.5-1 g IV / IM Every 12 hours 7-10 Severe Uncomplicated or Complicated Urinary Tract Infections, including pyelonephritis 2 g IV Every 12 hours 10 Moderate to Severe Uncomplicated Skin and Skin Structure Infections 2 g IV Every 12 hours 10 Complicated Intra-abdominal Infections (used in combination with metronidazole) 2 g IV Every 12 hours 7-10
Pediatric Patients (2 months up to 16 years):
The maximum dose for pediatric patients should not exceed the recommended adult dose. The usual recommended adult dose. The usual recommended dosage nin pediatric patients up to 40 kg in weight for durations as given above for adults is:
- 50 mg per kg per dose, administered every 12 hours for uncomplicated and complicated urinary tract infections (including pyelonephritis), uncomplicated skin and skin structure infections, and pneumonia (see below).
- For moderate to severe pneumonia due to P. aeruginosa give 50 mg per kg
per dose, every 8 hours.
- 50 mg per kg per dose, every 8 hours for febrile neutropenic patients.
Patients with Hepatic Impairment:
No adjustment is necessary for patients with hepatic impairment.
Patients with Renal Impairment:
In patients with creatinine clearance less than or equal to 60 mL/min, the dose of
Maxum (Cefepime) Injection should be adjusted to compensate for the slower rate
of renal elimination. The recommended initial dose of Maxum (Cefepime) Injection
should be the same as in patients with CrCL greater than 60 mL/Min except in
patients undergoing hemodialysis. The recommended doses of Maxum Injection in
patients with renal impairment are;
Recommended Dosing Schedule for Cefepime Injection in Adult Patients (Normal
Renal Function, Renal Impairment, and Hemodialysis)
Creatinine Clearance (Ml/min) Recommended Maintenance Schedule Greater than 60 500 mg every 12 hours 1 g every 12 hours 2 g every 12 hours 2 g every 8 hours 30-60 500 mg every 24 hours 1 g every 24 hours 2 g every 24 hours 2 g every 12 hours 11-29 500 mg every 24 hours 500 mg every 24 hours 1 g every 24 hours 2 g every 24 hours Less than 11 250 mg every 24 hours 250 mg every 24 hours 500 mg every 24 hours 1 g every 24 hours Continuous Ambulatory Peritoneal Dialysis (CAPD) 500 mg every 48 hours 1 g every 48 hours 2 g every 48 hours 2 g every 48 hours Hemodialysis 1 g on day 1 500 mg every 24 hours 1 g every 24 hours
In patients undergoing continuous ambulatory peritoneal dialysis, Maxum
(Cefepime) Injection may be administered at normally recommended doses at a
dosage interval of every 48 hours.
The dosage of Maxum (Cefepime) Injection for hemodialysis patients is 1 g on Day
1 followed by 500 mg every 24 hours for the treatment of all infections except febrile neutropenia, which is 1 g every 24 hours.
Maxum (Cefepime) Injection should be administered intravenously over approximately 30 minutes.
Intermittent intravenous infusion with a Y-type administration set can be accomplished with compatible solutions. However, during infusion of Maxum (Cefepime) Injection, it is desirable to discontinue the other solution. Solutions of cefepime, like those of most beta-lactam antibiotics, should not be added to solutions of ampicillin at a concentration greater than 40 mg per mL, and should not be added to metronidazole, vancomycin, gentamicin, tobramycin, netilmicin sulfate or aminophylline because of potential interaction. However, if concurrent therapy with cefepime is indicated, each of these antibiotics can be administered