CEFOPERAZONE + SULBACTAM (XORBACT)
Brand Name
Xorbact
Generic Name
Sulbactam sodium/cefoperazone sodium
Composition
Xorbact 500mg IM/IV Injection:
Each pack contains
Vial: Cefoperazone Sodium equivalent to Cefoperazone 250mg, Sulbactam Sodium equivalent to Sulbactam 250mg
Ampoule: Sterile water for Injection USP 5ml
Xorbact 1g IM/IV Injection:
Each pack contains:
Vial: Cefoperazone Sodium equivalent to Cefoperazone 500mg, Sulbactam Sodium equivalent to Sulbactam 500mg
Ampoule: Sterile water for Injection USP 5ml
Xorbact 2g IM/IV Injection:
Each pack contains:
Vial: Cefoperazone Sodium equivalent to Cefoperazone 1g, Sulbactam Sodium equivalent to Sulbactam 1g
Ampoule: Sterile water for Injection USP 10ml
Description
Sulbactam sodium/cefoperazone sodium combination is available as a dry powder for reconstitution in 1:1 in terms of free SBT/CPZ. Sulbactam sodium is a derivative of the basic penicillin nucleus. It is an irreversible beta-lactamase inhibitor for parenteral use only
Indications
Monotherapy
Cefoperazone/sulbactam is indicated for the treatment of the following infections when caused by susceptible organisms: Respiratory tract infections (Upper and lower) Urinary tract infections (Upper and lower) Peritonitis, cholecystitis, cholangitis, and other Intra-abdominal infections Septicemia Meningitis Skin and soft tissue infections bone and joint infections Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tract
Combination Therapy
Because of the broad-spectrum activity of cefoperazone/sulbactam, most infections can be treated adequately with this antibiotic alone. However, cefoperazonelsulbactam may be used concomitantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used, renal function should be monitored during the course of therapy
Presentation
Xorbact is supplied in the following dosage forms, strengths and pack sizes:
Xorbact Injection 500mg IM/IV:
1 vial of 250mg cefoperazone + 250mg sulbactam and 1 ampoule of 5ml water for injection.
Xorbact Injection 1g IM/IV:
1 vial of 500mg cefoperazone + 500mg sulbactam and 1 ampoule of 5ml water for injection.
Xorbact Injection 2g IM/IV:
1 vial of 1g cefoperazone + 1g sulbactam and 1 ampoule of 10ml water for injection.
