CEFOPERAZONE + SULBACTAM (XORBACT)
Sulbactam sodium/cefoperazone sodium combination is available as a dry powder for reconstitution in 1:1 in terms of free SBT/CPZ. Sulbactam sodium is a derivative of the basic penicillin nucleus. It is an irreversible beta-lactamase inhibitor for parenteral use only
Dosage and Administration
Daily dosage recommendations for sulbactam/cefoperazone in adults are as follows:
Ratio SBT/CPZ (g) Sulbactam Activity (g) Cefoperazone Activity (g) 1:1 2.0 _ 4.0 1.0 _ 2.0 1.0 _ 2.0
Doses should be administered every 12 hours in equally divided doses. In severe or refractory infections, the daily dosage of cefoperazone/sulbactam may be increased up to 8g of the 1:1 ratio (i.e. 4g Cefoperazone activity), patients receiving the 1:1 ratio may require additional cefoperazone administered separately. Doses should be administered every 12 hours in equally divided doses. The recommended maximum daily dosage of sulbactam is 4g.